Development of a Novel Biomarker for the Progression of Idiopathic Pulmonary Fibrosis.

ABSTRACT: The progression of idiopathic pulmonary fibrosis (IPF) is diverse and unpredictable. We identified and validated a new biomarker for IPF progression. To identify a candidate gene to predict progression, we assessed differentially expressed genes in patients with advanced IPF compared with early IPF and controls in three lung sample cohorts. Candidate gene expression was confirmed using immunohistochemistry and Western blotting of lung tissue samples from an independent IPF clinical cohort. Biomarker potential was assessed using an enzyme-linked immunosorbent assay of serum samples from the retrospective validation cohort. We verified that the final candidate gene reflected the progression of IPF in a prospective validation cohort. In the RNA-seq comparative analysis of lung tissues, CD2

SUBMITTER: Yeo HJ 

PROVIDER: S-EPMC10779374 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature