Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.

ABSTRACT: Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation, aberrant differentiation of keratinocytes, and dysregulated immune responses. WW domain-containing oxidoreductase (WWOX) is a non-classical tumor suppressor gene that regulates multiple cellular processes, including proliferation, apoptosis, and migration. This study aimed to explore the possible role of WWOX in the pathogenesis of psoriasis. Immunohistochemical analysis showed that the expression of WWOX was increased in epidermal keratinocytes of both human psoriatic lesions and imiquimod-induced mice psoriatic model. Immortalized human epidermal keratinocytes were transduced with a recombinant adenovirus expressing microRNA specific for WWOX to downregulate its expression. Inflammatory respon

SUBMITTER: Shin MJ 

PROVIDER: S-EPMC10779412 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature