Perturbation of Copper Homeostasis Sensitizes Cancer Cells to Elevated Temperature.

ABSTRACT: Temporary elevation of tumor temperature, also known as hyperthermia, is a safe and well-tolerated treatment modality. The efficacy of hyperthermia can be improved by efficient thermosensitizers, and various candidate drugs, including inhibitors of the heat stress response, have been explored in vitro and in animal models, but clinically relevant thermosensitizers are lacking. Here, we employ unbiased in silico approaches to uncover new mechanisms and compounds that could be leveraged to increase the thermosensitivity of cancer cells. We then focus on elesclomol, a well-performing compound, which amplifies cell killing by hyperthermia by 5- to 20-fold in cell lines and outperforms clinically applied chemotherapy when combined with hyperthermia in vitro. Surprisingly, our findings suggest t

SUBMITTER: Scutigliani EM 

PROVIDER: S-EPMC10779418 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature