Antileishmanial Effect of 1,5- and 1,8-Substituted Fused Naphthyridines.

ABSTRACT: In the absence of a vaccine, there is a need to find new drugs for the treatment of neglected tropical diseases, such as leishmaniasis, that can overcome the many drawbacks of those currently used. These disadvantages include cost, the need to maintain a cold chain, the route of administration, the associated adverse effects and the generation of resistance. In this work we have evaluated the antileishmanial effect of 1,5- and 1,8-substituted fused naphthyridines through in vitro and ex vivo assays, using genetically modified axenic and intramacrophagic Leishmania infantum amastigotes. The toxicity of these compounds has been tested in the mammalian host cell using murine splenic macrophages, as well as in murine intestinal organoids (miniguts) in order to assess their potential for

SUBMITTER: Melcon-Fernandez E 

PROVIDER: S-EPMC10780244 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature