Flavonoid Metabolites in Serum and Urine after the Ingestion of Selected Tropical Fruits.

ABSTRACT: The serum concentration and urinary excretion of flavonoids after the ingestion of guava, pineapple, and pomelo were determined using liquid chromatography-mass spectroscopy (LC-MS/MS). Each group of healthy volunteers was given 200 g of fresh fruit after overnight fasting and a 24-h flavonoid-free diet. The results demonstrate that only the glucuronic-conjugated metabolites of luteolin, quercetin, kaempferol, and myricetin were detected after fruit ingestion. The metabolites were first detected after 2 h, with the time to maximum concentration (T_max) at 6 h. The most abundant metabolites for guava, pineapple, and pomelo were the glucuronide metabolites of quercetin (AUC_0-8 5.4 ± 1.3 μg·h/mL), kaempferol (AUC_0-8 9.9 ± 2.3 μg·h/mL), and luteolin (AUC_0-8

SUBMITTER: Chomphen L 

PROVIDER: S-EPMC10780413 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature