Palladium-Catalyzed β-C(sp³)-H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands.

ABSTRACT: 2-Pyridone ligand-facilitated palladium-catalyzed direct C-H bond functionalization via the transient directing group strategy has become an attractive topic. Here, we report a Pd-catalyzed direct β-C(sp³)-H arylation reaction of tertiary aliphatic aldehydes by using an α-amino acid as a transient directing group in combination with a 2-pyridone ligand.

SUBMITTER: Xu Z 

PROVIDER: S-EPMC10780448 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature