Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study.

ABSTRACT: Rosmarinus officinalis L. compounds, especially its main polyphenolic compounds, carnosic acid (CA) and rosmarinic acid (RA), influence various facets of cancer biology, making them valuable assets in the ongoing fight against cancer. These two secondary metabolites exhibit formidable antioxidant properties that are a pivotal contributor against the development of cancer. Their antitumor effect has been related to diverse mechanisms. In the case of CA, it has the capacity to induce cell death of cancer cells through the rise in ROS levels within the cells, the inhibition of protein kinase AKT, the activation of autophagy-related genes (ATG) and the disrupt mitochondrial membrane potential. Regarding RA, its antitumor actions encompass apoptosis induction through caspas

SUBMITTER: Bouammali H 

PROVIDER: S-EPMC10780489 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature