Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells.

ABSTRACT: Prostate cancer is the most common cancer and the second leading cause of cancer deaths among men in the USA. Several studies have demonstrated the antitumor properties of saffron in different types of cancers, including prostate cancer. The oral administration of saffron extract has been reported to have antitumor effects on aggressive prostate-cancer-cell-line-derived xenografts in nude male mice. The objective of this study was to carry out in vitro studies of saffron-treated prostate cancer cells to ascertain the effects of saffron on key intermediates in prostate carcinogenesis. Our studies demonstrated the significant inhibition of cell proliferation for androgen-sensitive prostate cancer cell lines via apoptotic pathways. We also demonstrate the statistically significant down-regula

SUBMITTER: Khan M 

PROVIDER: S-EPMC10780623 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature