Serum lactate and mean arterial pressure thresholds in patients with cirrhosis and septic shock.

ABSTRACT:

Background

The Sepsis-3 guidelines have incorporated serum lactate levels of >2 mmol/L in septic shock definition to account for higher observed mortality. Further evidence is needed to support this threshold in cirrhosis, as well as target mean arterial pressure (MAP) during resuscitation.

Methods

This observational cohort study investigated the association between initial serum lactate and resuscitation MAP levels on in-hospital mortality in patients with and without cirrhosis. Patients admitted to the intensive care unit for the treatment of septic shock between 2006 and 2021 in a quaternary academic center were included. Patients with cirrhosis documented on imaging and International Classification of Disease codes (n=595) were compared to patients without cirrhosis (n=5

SUBMITTER: Smith TN 

PROVIDER: S-EPMC10781124 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature