The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution.

ABSTRACT:

Background and aims

Acute-on-chronic liver failure (ACLF) is a highly dynamic syndrome. The objective of this study was to delineate the clinical course of patients with HBV-ACLF and to develop a model to estimate the temporal evolution of disease severity.

Methods

We enrolled eligible patients from 2 large, multicenter prospective cohorts. The ACLF grade, organ failures, and outcomes were assessed at multiple time points (days 1/4/7/14/21/28). Probabilities for ACLF transitions between these disease states and to death within 28 days were calculated using a multi-state model that used baseline information and updated ACLF status. The model was validated in independent patients.

Results

Among all the 445 patients with HBV-ACLF, 76 represented disease progression, 195

SUBMITTER: Yu X 

PROVIDER: S-EPMC10781128 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature