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Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.
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ABSTRACT: Importance
Most studies investigating the characteristics of emerging SARS-CoV-2 variants have been focusing on mutations in the spike proteins that affect viral infectivity, fusogenicity, and pathogenicity. However, few studies have addressed how naturally occurring mutations in the non-spike regions of the SARS-CoV-2 genome impact virological properties. In this study, we proved that multiple SARS-CoV-2 Omicron BA.2 mutations, one in the spike protein and another downstream of the spike gene, orchestrally characterize this variant, shedding light on the importance of Omicron BA.2 mutations out of the spike protein.
SUBMITTER: Kimura I
PROVIDER: S-EPMC10781145 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.
Journal of virology 20231005 10
<h4>Importance</h4>Most studies investigating the characteristics of emerging SARS-CoV-2 variants have been focusing on mutations in the spike proteins that affect viral infectivity, fusogenicity, and pathogenicity. However, few studies have addressed how naturally occurring mutations in the non-<i>spike</i> regions of the SARS-CoV-2 genome impact virological properties. In this study, we proved that multiple SARS-CoV-2 Omicron BA.2 mutations, one in the spike protein and another downstream of t ...[more]