Trends in harmful drug exposure during pregnancy in France between 2013 and 2019: A nationwide cohort study.

ABSTRACT:

Objective

Describe the trends of exposure to harmful drugs during pregnancy over recent years in France.

Design

Nationwide cohort study.

Setting

The French National administrative health Data System (SNDS).

Population

Pregnancies starting between 2013 and 2019 and outcomes corresponding to live births, medical terminations of pregnancy, and stillbirths.

Methods

Each pregnancy was divided into a preconceptional period of 90 days before conception and three trimesters from conception to birth. Harmful drugs were defined according to their risks to the fetus: teratogenicity or fetotoxicity. Exposure was defined using the critical period during pregnancy for each type of harmful drug: preconceptional period or first trimester for teratogenic drugs and second

SUBMITTER: Louchet M 

PROVIDER: S-EPMC10781191 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature