Development of Liquid-Phase Plasmonic Sensor Platforms for Prospective Biomedical Applications.

ABSTRACT: Localized Surface Plasmon Resonance (LSPR) is an optical method for detecting changes in refractive index by the interaction between incident light and delocalized electrons within specific metal thin films' localized "hot spots". LSPR-based sensors possess advantages, including their compact size, enhanced sensitivity, cost-effectiveness, and suitability for point-of-care applications. This research focuses on the development of LSPR-based nanohole arrays (NHAs) as a platform for monitoring probe/target binding events in real time without labeling, for low-level biomolecular target detection in biomedical diagnostics. To achieve this objective, this study involves creating a liquid-phase setup for capturing target molecules. Finite-difference time-domain simulations revealed that a 75 nm

SUBMITTER: Sayin S 

PROVIDER: S-EPMC10781335 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature