Multiple NTS neuron populations cumulatively suppress food intake.

ABSTRACT: Several discrete groups of feeding-regulated neurons in the nucleus of the solitary tract (nucleus tractus solitarius; NTS) suppress food intake, including avoidance-promoting neurons that express Cck (NTS^Cck cells) and distinct Lepr- and Calcr-expressing neurons (NTS^Lepr and NTS^Calcr cells, respectively) that suppress food intake without promoting avoidance. To test potential synergies among these cell groups, we manipulated multiple NTS cell populations simultaneously. We found that activating multiple sets of NTS neurons (e.g. NTS^Lepr plus NTS^Calcr [NTS^LC], or NTS^LC plus NTS^Cck [NTS^LCK]) suppressed feeding more robustly than activating single populations. While

SUBMITTER: Qiu W 

PROVIDER: S-EPMC10781422 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature