Long non-coding RNA signature for predicting gastric cancer survival based on genomic instability.

ABSTRACT:

Background

Gastric cancer is a prevalent type of tumor with a poor prognosis. Given the high occurrence of genomic instability in gastric cancer, it is essential to investigate the prognostic significance of genes associated with genomic instability in this disease.

Methods

We identified genomic instability-related lncRNAs (GInLncRNAs) by analyzing somatic mutation and transcriptome profiles. We evaluated co-expression and enrichment using various analyses, including univariate COX analysis and LASSO regression. Based on these findings, we established an lncRNA signature associated with genomic instability, which we subsequently assessed for prognostic value, immune cell and checkpoint analysis, drug sensitivity, and external validation. Finally, PCR assay was used to verify

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10781445 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature