TMX family genes and their association with prognosis, immune infiltration, and chemotherapy in human pan-cancer.

ABSTRACT:

Background

The thioredoxin (TMX) system, an important redox system, plays crucial roles in several immune-related diseases. However, there is limited research on the correlation of TMX family gene expression with human pan-cancer prognosis, tumor microenvironment (TME), and immunotherapy.

Methods

Based on the integration of several bioinformatics analysis methods, we explored the expression levels and prognostic value of TMX family members in pan-cancer and analyzed their association between TME, immune infiltration, stemness scores, and drug sensitivity. Using KEGG enrichment analysis, we explored the potential signaling pathways of their regulation. Additionally, we conducted a transwell assay to verify the relationship between TMX family gene expression and epithelial-mes

SUBMITTER: Luo N 

PROVIDER: S-EPMC10781458 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature