Novel insights into the regulatory role of N6-methyladenosine methylation modified autophagy in sepsis.

ABSTRACT: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is characterized by high morbidity and mortality and one of the major diseases that seriously hang over global human health. Autophagy is a crucial regulator in the complicated pathophysiological processes of sepsis. The activation of autophagy is known to be of great significance for protecting sepsis induced organ dysfunction. Recent research has demonstrated that N6-methyladenosine (m⁶A) methylation is a well-known post-transcriptional RNA modification that controls epigenetic and gene expression as well as a number of biological processes in sepsis. In addition, m⁶A affects the stability, export, splicing and translation of transcripts involved in the

SUBMITTER: Bi CF 

PROVIDER: S-EPMC10781468 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature