Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes.

ABSTRACT: Digested dietary fats are taken up by enterocytes where they are assembled into pre-chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation and subsequent secretion to the circulation¹. The role of mitochondria in dietary lipid processing is unclear. Here we show that mitochondrial dysfunction in enterocytes inhibits chylomicron production and the transport of dietary lipids to peripheral organs. Mice with specific ablation of the mitochondrial aspartyl-tRNA synthetase DARS2 (ref. ²), the respiratory chain subunit SDHA³ or the assembly factor COX10 (ref. ⁴) in intestinal epithelial cells showed accumulation of large lipid droplets (LDs) in enterocytes of the proximal small intestine and failed to thrive. Feedin

SUBMITTER: Moschandrea C 

PROVIDER: S-EPMC10781618 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature