TAF15 amyloid filaments in frontotemporal lobar degeneration.

ABSTRACT: Frontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer's disease, and is often also associated with motor disorders¹. The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins². In the majority of cases the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterizing different FTLD subtypes^3,4. The presence of amyloid filaments and their identities and structures in the remaining approximately 10% of FTLD cases are unknown but are widely believed to be composed of the protein fused in sarcoma (FUS, also known as translocated in liposarcoma). As such, these cases

SUBMITTER: Tetter S 

PROVIDER: S-EPMC10781619 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature