Ontology highlight
ABSTRACT:
SUBMITTER: Nakatani T
PROVIDER: S-EPMC10781638 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Nakatani Tsunetoshi T Schauer Tamas T Altamirano-Pacheco Luis L Klein Kyle N KN Ettinger Andreas A Pal Mrinmoy M Gilbert David M DM Torres-Padilla Maria-Elena ME
Nature 20231220 7994
DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs with a defined temporal order known as the replication timing (RT) programme, leading to organization of the genome into early- or late-replicating regions. RT is cell-type specific, is tightly linked to the three-dimensional nuclear organization of the genome<sup>1,2</sup> and is considered an epigenetic fingerprint<sup>3</sup>. In spite of its importance in maintaining the epigenome<sup>4</sup>, the dev ...[more]