Minute-scale oscillatory sequences in medial entorhinal cortex.

ABSTRACT: The medial entorhinal cortex (MEC) hosts many of the brain's circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations of experience¹. Whereas location is known to be encoded by spatially tuned cell types in this brain region^2,3, little is known about how the activity of entorhinal cells is tied together over time at behaviourally relevant time scales, in the second-to-minute regime. Here we show that MEC neuronal activity has the capacity to be organized into ultraslow oscillations, with periods ranging from tens of seconds to minutes. During these oscillations, the activity is further organized into periodic sequences. Oscillatory sequences manifested while mice ran at free pace on a ro

SUBMITTER: Gonzalo Cogno S 

PROVIDER: S-EPMC10781645 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature