Dictionary of immune responses to cytokines at single-cell resolution.

ABSTRACT: Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets^1-3. A myriad of studies have highlighted their central role in immune function^4-13, yet we lack a global view of the cellular responses of each immune cell type to each cytokine. To address this gap, we created the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. A cytokine-centric view of the dictionary revealed that most cytokines induce highly cell-type-specific responses. For example, the inflammatory cytokine interleukin-1β induces distinct gene programmes in almost every cell type. A cell-type-cen

SUBMITTER: Cui A 

PROVIDER: S-EPMC10781646 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature