Unveiling the mechanistic link between extracellular amyloid fibrils, mechano-signaling and YAP activation in cancer.

ABSTRACT: The tumor microenvironment is a complex ecosystem that plays a critical role in cancer progression and treatment response. Recently, extracellular amyloid fibrils have emerged as novel components of the tumor microenvironment; however, their function remains elusive. In this study, we establish a direct connection between the presence of amyloid fibrils in the secretome and the activation of YAP, a transcriptional co-activator involved in cancer proliferation and drug resistance. Furthermore, we uncover a shared mechano-signaling mechanism triggered by amyloid fibrils in both melanoma and pancreatic ductal adenocarcinoma cells. Our findings highlight the crucial role of the glycocalyx protein Agrin which binds to extracellular amyloid fibrils and acts as a necessary factor in driving amylo

SUBMITTER: Farris F 

PROVIDER: S-EPMC10781709 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature