Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent.

ABSTRACT: Multiple Myeloma is a typical example of a neoplasm that shows significant differences in incidence, age of onset, type, and frequency of genetic alterations between patients of African and European ancestry. This perspective explores the hypothesis that both genetic polymorphisms and spontaneous somatic mutations in the TP53 tumor suppressor gene are determinants of these differences. In the US, the rates of occurrence of MM are at least twice as high in African Americans (AA) as in Caucasian Americans (CA). Strikingly, somatic TP53 mutations occur in large excess (at least 4-6-fold) in CA versus AA. On the other hand, TP53 contains polymorphisms specifying amino-acid differences that are under natural selection by the latitude of a population and have evolved during the migrations of hum

SUBMITTER: Levine AJ 

PROVIDER: S-EPMC10781774 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature