Endolysin NC5 improves early cloxacillin treatment in a mouse model of Streptococcus uberis mastitis.

ABSTRACT: Streptococcus uberis frequently causes bovine mastitis, an infectious udder disease with significant economic implications for dairy cows. Conventional antibiotics, such as cloxacillin, sometimes have limited success in eliminating S. uberis as a stand-alone therapy. To address this challenge, the study objective was to investigate the VersaTile engineered endolysin NC5 as a supplemental therapy to cloxacillin in a mouse model of bovine S. uberis mastitis. NC5 was previously selected based on its intracellular killing and biofilm eradicating activity. To deliver preclinical proof-of-concept of this supplemental strategy, lactating mice were intramammarily infected with a bovine S. uberis field isolate and subsequently treated with cloxacillin (30.0 μg) combined with either a low (23.5 μg)

SUBMITTER: Vander Elst N 

PROVIDER: S-EPMC10781846 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature