Cleavage of cell junction proteins as a host invasion strategy in leptospirosis.

ABSTRACT: Infection and invasion are the prerequisites for developing the disease symptoms in a host. While the probable mechanism of host invasion and pathogenesis is known in many pathogens, very little information is available on Leptospira invasion/pathogenesis. For causing systemic infection Leptospira must transmigrate across epithelial barriers, which is the most critical and challenging step. Extracellular and membrane-bound proteases play a crucial role in the invasion process. An extensive search for the proteins experimentally proven to be involved in the invasion process through cell junction cleavage in other pathogens has resulted in identifying 26 proteins. The similarity searches on the Leptospira genome for counterparts of these 26 pathogenesis-related proteins identified at least 1

SUBMITTER: Kumari P 

PROVIDER: S-EPMC10781872 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature