Human gut microbiome: Therapeutic opportunities for metabolic syndrome-Hype or hope?

ABSTRACT: Shifts in gut microbiome composition and metabolic disorders are associated with one another. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Diet, intake of probiotics or prebiotics and faecal microbiome transplantation (FMT) are methods to alter a person's microbiome composition. Although FMT may allow establishing a proof of concept to use microbiome modulation to treat metabolic disorders, studies show mixed results regarding the effects on metabolic parameters as well as on the composition of the microbiome. This review summarizes the current knowledge on diet, probiotics, prebiotics and FMT to treat metabolic diseases, focusing on studies that also report alterations in microbiome composition. Furthermore

SUBMITTER: Horvath A 

PROVIDER: S-EPMC10781898 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature