Comparison of tracer kinetic models for ⁶⁸Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients.

ABSTRACT:

Background

⁶⁸Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified as standard uptake values (SUVs) for clinical decision-making. However, analysis of dynamic images characterizing both tracer uptake and pharmacokinetics may offer added insights into the underlying tissue pathophysiology. This study was undertaken to evaluate the suitability of various kinetic models for ⁶⁸Ga-PSMA-11 PET analysis. Twenty-three lesions in 18 patients were included in a retrospective kinetic evaluation of 55-min dynamic ⁶⁸Ga-PSMA-11 pre-prostatectomy PET scans from patients with biopsy-demonstrated intermediate- to h

SUBMITTER: Smith NJ 

PROVIDER: S-EPMC10781928 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature