Altered sleep behavior strengthens face validity in the ArcAβ mouse model for Alzheimer's disease.

ABSTRACT: Demographic changes will expand the number of senior citizens suffering from Alzheimer's disease (AD). Key aspects of AD pathology are sleep impairments, associated with onset and progression of AD. AD mouse models may provide insights into mechanisms of AD-related sleep impairments. Such models may also help to establish new biomarkers predicting AD onset and monitoring AD progression. The present study aimed to establish sleep-related face validity of a widely used mouse model of AD (ArcAβ model) by comprehensively characterizing its baseline sleep/wake behavior. Chronic EEG recordings were performed continuously on four consecutive days in freely behaving mice. Spectral and temporal sleep/wake parameters were assessed and analyzed. EEG recordings showed decreased non-rapid eye movement

SUBMITTER: Altunkaya A 

PROVIDER: S-EPMC10781983 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature