A comparison of visual and acoustic mismatch negativity as potential biomarkers in schizophrenia.

ABSTRACT: Mismatch negativity (MMN) is an event-related potential (ERP) component generated when an unexpected deviant stimulus occurs in a pattern of standard stimuli. Several studies showed that the MMN response to both auditory and visual stimuli is attenuated in schizophrenia. While previous studies investigated auditory and visual MMN in different cohorts, here we examined the potential clinical utility of MMN responses to auditory and visual stimuli within the same group of patients. Altogether 39 patients with schizophrenia and 39 healthy controls matched in age, gender, and education were enrolled. We recorded EEG using 64 channels in eight experimental blocks where we presented auditory and visual stimulus sequences. Mismatch responses were obtained by subtracting responses to standard from

SUBMITTER: Molnar H 

PROVIDER: S-EPMC10782025 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature