Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis.

ABSTRACT: Intestinal epithelial renewal, which depends on the proliferation and differentiation of intestinal stem cells (ISCs), is essential for epithelial homoeostasis. Understanding the mechanism controlling ISC activity is important. We found that death receptor 5 (DR5) gene deletion (DR5^-/-) mice had impaired epithelial absorption and barrier function, resulting in delayed weight gain, which might be related to the general reduction of differentiated epithelial cells. In DR5^-/- mice, the expression of ISC marker genes, the number of Olfm4⁺ ISCs, and the number of Ki67⁺ and BrdU⁺ cells in crypt were reduced. Furthermore, DR5 deletion inhibited the expression of lineage differentiation genes driving ISC differentiation into enterocytes, goble

SUBMITTER: Liu J 

PROVIDER: S-EPMC10782029 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature