Links among MRI features in paraspinal muscles, inflammatory processes, and related back pain in patients with lumbar disc herniation.

ABSTRACT:

Background

Recent studies have provided evidence that structural changes in paraspinal muscles are associated with intervertebral disc degeneration (IDD), ubiquitous with low back pain (LBP), and potentially thought to be regulated by inflammatory processes. However, the links remain unclear.

Objective

The aims of this study were to investigate structural changes in paraspinal muscles that differed in healthy and lumbar disc herniation (LDH) patients, and LDH patients with and without LBP, and to determine the link with the expression of inflammatory marker(s).

Methods

Cross-sectional areas (CSAs) and fatty degeneration of muscles were measured in this prospective cohort study. Multifidus muscle (MM) tissue was procured from included individuals undergoing surgery. Ge

SUBMITTER: Chen X 

PROVIDER: S-EPMC10782065 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature