An observational cohort study on the effects of extended postoperative antibiotic prophylaxis on surgical-site infections in low- and middle-income countries.

ABSTRACT:

Background

Worldwide, approximately one in six inpatient antibiotic prescriptions are for surgical-infection prophylaxis, including postoperative prophylaxis. The WHO recommends against prolonged postoperative antibiotics to prevent surgical-site infection. However, in many low- and middle-income countries, postoperative antibiotic prophylaxis is common due to perceptions that it protects against surgical-site infection and data informing recommendations against antibiotic administration are largely derived from high-income countries. The aim of this study was to describe postoperative antibiotic-prescribing patterns and related surgical-site infection rates in hospitals in low- and middle-income countries.

Methods

Patients from 19 hospitals in Ethiopia, Madagascar, India, a

SUBMITTER: Clean Cut Investigators Group 

PROVIDER: S-EPMC10782210 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature