Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: A meta-analysis.

ABSTRACT:

Background

The role of interleukin-12(IL-12) gene +1188A/C polymorphism has been indicated in the progression of tuberculosis (TB). Nevertheless, the outcomes remain controversial.

Objectives

This meta-analysis focused on examining the association between IL-12 +1188A/C polymorphism and TB.

Methods

EMBASE and PubMed databases were searched to identify relevant studies for retrospective analysis. Then, a random- or fixed-effects model was utilized to calculate the combined odds ratios (ORs) as well as corresponding 95% confidence intervals (CIs).

Results

A total of 9 related articles were discovered. The result of meta-analysis showed that IL-12 +1188A/C polymorphism did not show significant correlation with TB risk among the total populatio

SUBMITTER: Wang P 

PROVIDER: S-EPMC10782329 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature