Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies.
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ABSTRACT: Introduction
c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This study is aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis of hematological malignancies.Methods
Plasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster of differentiation markers performed via immunocytochemistry.Result
Plasma c-MYC was higher in subject with hematological malignancies (8.8 ± 1.1) when compared with apparently healthy controls (4.5 ± 0.5). A screening cut-off c-MYC ratio value of 9.42 with sensitivity and specificity of 65.5% and 100% respectively were obtained using receiver operator characteristic curve analysis. Plasma c-MYC was found to have no prognostic value using Kaplan-Meier analysis.Conclusion
Plasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.
SUBMITTER: Okafor IM
PROVIDER: S-EPMC10782349 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Publications
Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies.
Okafor Ifeyinwa Maryann IM Okoroiwu Henshaw Uchechi HU Ogar Christopher Ogar CO
African health sciences 20230601 2
<h4>Introduction</h4>c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This study is aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis of hematological malignancies.<h4>Methods</h4>Plasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster of differentiation markers performed via immunocytochemistry.<h4>Result</h4>Plasma c-MYC wa ...[more]
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