Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents.

ABSTRACT:

Study objectives

Although insufficient sleep is a risk factor for metabolic syndrome (MetS), the circadian timing of sleep (CTS) is also involved in cardiac and metabolic regulation. We examined whether delays and deviations in the sleep midpoint (SM), a measure of CTS, modify the association between visceral adipose tissue (VAT) and MetS in adolescents.

Methods

We evaluated 277 adolescents (median 16 years) who had at least 5 nights of at-home actigraphy (ACT), in-lab polysomnography (PSG), dual-energy X-ray absorptiometry (DXA) scan, and MetS score data. Sleep midpoint (SM), sleep irregularity (SI), and social jetlag (SJL) were examined as effect modifiers of the association between VAT and MetS, including waist circumference, blood pressure, insulin resistance, triglyceri

SUBMITTER: Morales-Ghinaglia N 

PROVIDER: S-EPMC10782492 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature