Insulin resistance-related features are associated with cognitive decline: a cross-sectional study in adult patients with type 1 diabetes.

ABSTRACT:

Background

To investigate the associations between insulin resistance (IR)-related features and cognitive function in type 1 diabetes (T1D).

Methods

A total of 117 adult patients with T1D were recruited in this cross-sectional study. IR-related features include overweight/obesity/central obesity, hypertension, atherogenic dyslipidemia, and decreased estimated insulin sensitivity (eIS). The Wechsler Memory Scale-Chinese Revision, Wisconsin Card Sorting Test, and Sustained Attention to Response Task was used to assess memory, executive function and sustained attention, respectively. A z-score was generated from each test, and a composite measure of global cognitive performance was calculated by averaging the z-scores of all tests. Cognitive differences were measured between T1

SUBMITTER: Ji X 

PROVIDER: S-EPMC10782534 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature