Identification of potential biomarkers and therapeutic targets related to post-traumatic stress disorder due to traumatic brain injury.

ABSTRACT:

Background

Post-traumatic stress disorder (PTSD), a disease state that has an unclear pathogenesis, imposes a substantial burden on individuals and society. Traumatic brain injury (TBI) is one of the most significant triggers of PTSD. Identifying biomarkers associated with TBI-related PTSD will help researchers to uncover the underlying mechanism that drives disease development. Furthermore, it remains to be confirmed whether different types of traumas share a common mechanism of action.

Methods

For this study, we screened the eligible data sets from the Gene Expression Omnibus (GEO) database, obtained differentially expressed genes (DEGs) through analysis, conducted functional enrichment analysis on the DEGs in order to understand their molecular mechanisms, constructed a P

SUBMITTER: Qi P 

PROVIDER: S-EPMC10782540 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature