Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults.

ABSTRACT:

Objectives

Dietary restriction of methionine (Met) and cysteine (Cys) delays the aging process and aging-related diseases, improves glucose and fat metabolism and reduces oxidative stress in numerous laboratory animal models. Little is known regarding the effects of sulfur amino acid restriction in humans. Thus, our objectives were to determine the impact of feeding diets restricted in Met alone (MetR) or in both Met and Cys (total sulfur amino acids, SAAR) to healthy adults on relevant biomarkers of cardiometabolic disease risk.

Design

A controlled feeding study.

Setting and participants

We included 20 healthy adults (11 females/9 males) assigned to MetR or SAAR diet groups consisting of three 4-wk feeding periods: Control period; low level restriction period (70% Me

SUBMITTER: Richie JP 

PROVIDER: S-EPMC10782544 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature