Clinical outcomes and prognostic factors in triple-negative invasive lobular carcinoma of the breast.

ABSTRACT:

Purpose

Triple-negative invasive lobular carcinoma (TN-ILC) of breast cancer is a rare disease and the clinical outcomes and prognostic factors are not well-defined.

Methods

Women with stage I-III TN-ILC or triple-negative invasive ductal carcinoma (TN-IDC) of the breast undergoing mastectomy or breast-conserving surgery between 2010 and 2018 in the National Cancer Database were included. Kaplan-Meier curves and multivariate Cox proportional hazard regression were used to compare overall survival (OS) and evaluate prognostic factors. Multivariate logistic regression was performed to analyze the factors associated with pathological response to neoadjuvant chemotherapy.

Results

The median age at diagnosis for women with TN-ILC was 67 years compared to 58 years in TN-IDC

SUBMITTER: Joshi U 

PROVIDER: S-EPMC10782581 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature