TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression.

ABSTRACT:

Background

As a novel necrosis manner, ferroptosis has been increasingly reported to play a role in tumor progression and treatment, however, the specific mechanisms underlying its development in prostate cancer remain unclear. Growing evidence showed that peroxisome plays a key role in ferroptosis. Herein, we identified a novel mechanism for the involvement of ferroptosis in prostate cancer progression, which may provide a new strategy for clinical treatment of prostate cancer.

Methods

Label-Free Mass spectrometry was used to screen and identify candidate proteins after ferroptosis inducer-ML210 treatment. Immunohistochemistry was undertaken to explore the protein expression of AGPS in prostate cancer tissues compared with normal tissues. Co-immunoprecipitation and GST pull

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10782585 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature