Putative causal relations among gut flora, serums metabolites and arrhythmia: a Mendelian randomization study.

ABSTRACT:

Background

The pathogenesis of cardiac arrhythmias is multifaceted, encompassing genetic, environmental, hemodynamic, and various causative factors. Emerging evidence underscores a plausible connection between gut flora, serum metabolites, and specific types of arrhythmias. Recognizing the role of host genetics in shaping the microbiota, we employed two-sample Mendelian randomization analyses to investigate potential causal associations between gut flora, serum metabolites, and distinct arrhythmias.

Methods

Mendelian randomization methods were deployed to ascertain causal relationships between 211 gut flora, 575 serum metabolites, and various types of arrhythmias. To ensure the reliability of the findings, five complementary Mendelian randomization methods, including inverse

SUBMITTER: Li K 

PROVIDER: S-EPMC10782588 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature