Development and validation of epigenetic modification-related signals for the diagnosis and prognosis of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the world's most common malignancies. Epigenetics is the study of heritable changes in characteristics beyond the DNA sequence. Epigenetic information is essential for maintaining specific expression patterns of genes and the normal development of individuals, and disorders of epigenetic modifications may alter the expression of oncogenes and tumor suppressor genes and affect the development of cancer. This study elucidates the relationship between epigenetics and the prognosis of CRC patients by developing a predictive model to explore the potential value of epigenetics in the treatment of CRC.

Methods

Gene expression data of CRC patients' tumor tissue and controls were downloaded from GEO database. Combined with the 720 epigenet

SUBMITTER: Li X 

PROVIDER: S-EPMC10782594 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature