Comparison of effect estimates between preprints and peer-reviewed journal articles of COVID-19 trials.

ABSTRACT:

Background

Preprints are increasingly used to disseminate research results, providing multiple sources of information for the same study. We assessed the consistency in effect estimates between preprint and subsequent journal article of COVID-19 randomized controlled trials.

Methods

The study utilized data from the COVID-NMA living systematic review of pharmacological treatments for COVID-19 (covid-nma.com) up to July 20, 2022. We identified randomized controlled trials (RCTs) evaluating pharmacological treatments vs. standard of care/placebo for patients with COVID-19 that were originally posted as preprints and subsequently published as journal articles. Trials that did not report the same analysis in both documents were excluded. Data were extracted independently by pairs

SUBMITTER: Davidson M 

PROVIDER: S-EPMC10782611 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature