Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status.

ABSTRACT:

Background

APOE4 is the strongest genetic risk factor for sporadic Alzheimer's disease (AD), whereas APOE2 confers protection. However, effects of APOE on neurodegeneration in cognitively intact individuals, and how these associations evolve with cognitive decline, are unclear. Furthermore, few studies have evaluated whether effects of APOE on neurodegenerative changes are modified by other AD key risk factors including age and sex.

Methods

Participants included older adults (57% women; 77 ± 7 years) from the Rancho Bernardo Study of Health Aging and the University of California San Diego Alzheimer's Disease Research Center, including 192 cognitively normal (CN) individuals and 33 with mild cognitive impairment. Participants underwent diffusion MRI, and multicompartment rest

SUBMITTER: Reas ET 

PROVIDER: S-EPMC10782616 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature