Lipoxins A₄ and B₄ inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation.

ABSTRACT: Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A₄ and B₄ (LXA₄ and LXB₄) have protective activities against neurodegenerative injury. Yet, lipoxin activities and downstream signaling in neuroinflammatory processes are not well understood. Here, we utilized a model of posterior uveitis induced by lipopolysaccharide endotoxin (LPS), which results in rapid retinal neuroinflammation primarily characterized by activation of resident macroglia (astrocytes and Müller glia), and microglia. Using this model, we observed that each lipoxin reduces acute inner retinal inflammation by affecting endogenous glial responses in a cascading sequence b

SUBMITTER: Livne-Bar I 

PROVIDER: S-EPMC10782675 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature