Mismatch negativity and clinical trajectories in psychotic disorders: Five-year stability and predictive utility.

ABSTRACT:

Background

Mismatch negativity (MMN) amplitude is reduced in psychotic disorders and associated with symptoms and functioning. Due to these robust associations, it is often considered a biomarker for psychotic illness. The relationship between MMN and clinical outcomes has been examined well in early onset psychotic illness; however, its stability and predictive utility in chronic samples are not clear.

Method

We examined the five-year stability of MMN amplitude over two timepoints in individuals with established psychotic disorders (cases; N = 132) and never-psychotic participants (NP; N = 170), as well as longitudinal associations with clinical symptoms and functioning.

Results

MMN amplitude exhibited good temporal stability (cases, r = 0.53; ne

SUBMITTER: Donaldson KR 

PROVIDER: S-EPMC10782876 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature