Streptococcus pneumoniae serotype 33G: genetic, serological, and structural analysis of a new capsule type.

ABSTRACT:

Importance

Streptococcus pneumoniae (the pneumococcus) is a bacterial pathogen with the greatest burden of disease in Asia and Africa. The pneumococcal capsular polysaccharide has biological relevance as a major virulence factor as well as public health importance as it is the target for currently licensed vaccines. These vaccines have limited valency, covering up to 23 of the >100 known capsular types (serotypes) with higher valency vaccines in development. Here, we have characterized a new pneumococcal serotype, which we have named 33G. We detected serotype 33G in nasopharyngeal swabs (n = 20) from children and adults hospitalized with pneumonia, as well as healthy children in Mongolia. We show that the genetic, serological, and biochemical properties of 33G differ

SUBMITTER: Manna S 

PROVIDER: S-EPMC10782959 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature