Strategies for high cell density cultivation of Akkermansia muciniphila and its potential metabolism.

ABSTRACT:

Importance

Currently, there is significant interest in Akkermansia muciniphila as a promising next-generation probiotic, making it a hot topic in scientific research. However, to achieve efficient industrial production, there is an urgent need to develop an in vitro culture method to achieve high biomass using low-cost carbon sources such as glucose. This study aims to explore the high-density fermentation strategy of A. muciniphila by optimizing the culture process. This study also employs techniques such as LC-MS and RNA-Seq to explain the possible regulatory mechanism of high-density cell growth and increased cell surface hydrophobicity facilitating cell colonization of the gut in vitro culture. Overall, this research sheds light on the potential of <

SUBMITTER: Wu H 

PROVIDER: S-EPMC10782997 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature