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Strategies for high cell density cultivation of Akkermansia muciniphila and its potential metabolism.

ABSTRACT:

Importance

Currently, there is significant interest in Akkermansia muciniphila as a promising next-generation probiotic, making it a hot topic in scientific research. However, to achieve efficient industrial production, there is an urgent need to develop an in vitro culture method to achieve high biomass using low-cost carbon sources such as glucose. This study aims to explore the high-density fermentation strategy of A. muciniphila by optimizing the culture process. This study also employs techniques such as LC-MS and RNA-Seq to explain the possible regulatory mechanism of high-density cell growth and increased cell surface hydrophobicity facilitating cell colonization of the gut in vitro culture. Overall, this research sheds light on the potential of A. muciniphila as a probiotic and provides valuable insights for future industrial production.

SUBMITTER: Wu H

PROVIDER: S-EPMC10782997 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Strategies for high cell density cultivation of Akkermansia muciniphila and its potential metabolism.

Wu Haiting H Qi Shuhua S Yang Ruixiong R Pan Qihua Q Lu Yinghua Y Yao Chuanyi C He Ning N Huang Song S Ling Xueping X

Microbiology spectrum 20231207 1

<h4>Importance</h4>Currently, there is significant interest in Akkermansia muciniphila as a promising next-generation probiotic, making it a hot topic in scientific research. However, to achieve efficient industrial production, there is an urgent need to develop an in vitro culture method to achieve high biomass using low-cost carbon sources such as glucose. This study aims to explore the high-density fermentation strategy of A. muciniphila by optimizing the culture process. ...[more]

PMID: 38059626

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