Gastric coinfection with thiopeptide-positive <i>Cutibacterium acnes</i> decreases FOXM1 and pro-inflammatory biomarker expression in a murine model of <i>Helicobacter pylori</i>-induced gastric cancer.

ABSTRACT:

Importance

H. pylori infects half of the world population and is the leading cause of gastric cancer. We previously demonstrated that gastric cancer risk is associated with gastric microbiota. Specifically, gastric urease-positive Staphylococcus epidermidis and Streptococcus salivarius had contrasting effects on H. pylori-associated gastric pathology and immune responses in germ-free INS-GAS mice. As gastritis progresses to gastric cancer, the oncogenic transcription factor Foxm1 becomes increasingly expressed. In this study, we evaluated the gastric commensal C. acnes, certain strains of which produce thiopeptides that directly inhibit FOXM1. Thiopeptide-positive C. acnes was isolated from Nicaraguan patient gastric biopsies and ino

SUBMITTER: Lunger C 

PROVIDER: S-EPMC10783005 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature